Transgene is designing and developing next-generation immunotherapeutics against cancer
TG4050
One patient, one cancer, one vaccine
TG4050 is an individualized neoantigen cancer vaccines from Transgene’s myvac® platform, based on multiple advanced genetic engineering technologies and cutting-edge artificial intelligence capabilities. TG4050 is being evaluated in a Phase I/II clinical trial.
TG4050 video
Watch Alessandro Riva presenting first clinical benefits of neoantigen cancer vaccine, TG4050, in head & neck cancer at AACR 2024
Innovative technologies
Push the boundaries of immunotherapy
Transgene combines cutting-edge technologies, a multidisciplinary team and a prestigious international network.
Discover our myvac® platform
Discover our invir.IO® platform
Oncolytic viruses
A new generation of products
These innovative multifunctional OVs, from Transgene’s invir.IO® platform, are able to modulate the tumor microenvironment to better attack cancer.
Oncolytic viruses video
Three therapeutic approaches
Transgene’s immunotherapies harness the mechanisms of the immune response to enable the patient’s body to fight against disease.
- ASCO 2025
ASCO 2025
Transgene to Present 24-month Disease-Free Survival Data from All Patients in Phase I Part of Trial of Individualized Cancer Vaccine, TG4050, at ASCO 2025
Donwload Press release (PDF) - Presentation
Transgene in a nutshell
Corporate Presentation
Universal Registration Document
Press releases
- May 22, 2025 - Transgene to Present 24-month Disease-Free Survival Data from All Patients in Phase I Part of Trial of Individualized Cancer Vaccine, TG4050, at ASCO 2025
- May 15, 2025 - Transgene’s Combined General Meeting of May 15, 2025
- April 24, 2025 - Transgene Provides Business and Financial Update for Q1 2025
Last publications
- May 22, 2025 - Randomized phase I trial of adjuvant personalized cancer vaccine TG4050 inresected locally advanced (LA) head and neck squamous cell carcinoma (HNSCC)patients (pts)
- May 22, 2025 - Randomized phase II trial evaluating the combination of TG4001, a HPV16 therapeutic vaccineand avelumab (ave) in patients (pts) with immunotherapy-naïve recurrent and/or metastatic(R/M) HPV16-positive cervical or anogenital cancer
- November 7, 2024 - Randomized phase I trial of adjuvant individualized TG4050 vaccine in patients with locally advanced resected HPV-negative head and neck squamous cell carcinoma (HNSCC)

ASCO 2025
Transgene Presents 24-Month Relapse-Free Survival Data for All Patients in Phase I Study of its Individualized Therapeutic Vaccine TG4050 at ASCO 2025
➜ Download the press release (PDF)